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Roseburia

Roseburia is a beneficial gut microbe that plays a crucial role in human health for several reasons. It plays roles in producing butyrate, regulating inflammation, and maintaining gut barrier function. Roseburia also inhibits harmful bacteria, and it is associated with a reduced risk of obesity, type 2 diabetes, and inflammatory diseases. Let’s take a look at these in more detail:

  1. Butyrate production: Roseburia is a significant producer of butyrate, a short-chain fatty acid that serves as an energy source for colon cells, promoting their health and function.1Nie K, Ma K, Luo W, Shen Z, Yang Z, Xiao M, Tong T, Yang Y, Wang X. Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species. Front Cell Infect Microbiol. 2021 Nov 22;11:757718. doi: 10.3389/fcimb.2021.757718.2La Rosa, S.L., Leth, M.L., Michalak, L. et al. The human gut Firmicute Roseburia intestinalis is a primary degrader of dietary β-mannans. Nat Commun 10, 905 (2019). doi: 10.1038/s41467-019-08812-y
  2. Anti-inflammatory properties: Roseburia, through its production of butyrate, has anti-inflammatory effects, helping to regulate the immune system and reduce excessive inflammation in the gut and throughout the body.3Machiels K, Joossens M, Sabino J, De Preter V, Arijs I, Eeckhaut V, Ballet V, Claes K, Van Immerseel F, Verbeke K, Ferrante M, Verhaegen J, Rutgeerts P, Vermeire S. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Gut. 2014 Aug;63(8):1275-83. doi: 10.1136/gutjnl-2013-304833.4Ruan G, Chen M, Chen L, Xu F, Xiao Z, Yi A, Tian Y, Ping Y, Lv L, Cheng Y, Wei Y. Roseburia intestinalis and Its Metabolite Butyrate Inhibit Colitis and Upregulate TLR5 through the SP3 Signaling Pathway. Nutrients. 2022 Jul 25;14(15):3041. doi: 10.3390/nu14153041.5Shen Z, Luo W, Tan B, Nie K, Deng M, Wu S, Xiao M, Wu X, Meng X, Tong T, Zhang C, Ma K, Liao Y, Xu J, Wang X. Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn’s disease. EBioMedicine. 2022 Nov;85:104285. doi: 10.1016/j.ebiom.2022.104285.
  3. Gut barrier function: By producing butyrate, Roseburia supports the integrity of the gut lining, preventing harmful substances and pathogens from entering the bloodstream and contributing to overall gut health.6Nie K, Ma K, Luo W, Shen Z, Yang Z, Xiao M, Tong T, Yang Y, Wang X. Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species. Front Cell Infect Microbiol. 2021 Nov 22;11:757718. doi: 10.3389/fcimb.2021.757718.
  4. Inhibiting harmful bacteria: Roseburia may help suppress the growth of harmful bacteria in the gut, thus preventing their overgrowth and related health issues.7Faruqui, N. A., Prium, D. H., Mowna, S. A., Ullah, M. A., Araf, Y., Sarkar, B., Rahman, M. S. (2021). Gut microorganisms and neurological disease perspectives. Future Neurology, 16(1), FNL53. doi: 10.2217/fnl-2020-00268Hatziioanou D, Mayer MJ, Duncan SH, Flint HJ, Narbad A. A representative of the dominant human colonic Firmicutes, Roseburia faecis M72/1, forms a novel bacteriocin-like substance. Anaerobe. 2013 Oct;23:5-8. doi: 10.1016/j.anaerobe.2013.07.006.
  5. Association with health: Clinical research suggests that abundant levels of Roseburia have been linked to a lower risk of developing various health issues, such as obesity, type 2 diabetes, and inflammatory bowel disease (IBD). As a rule of thumb, the results from these studies can be interpreted to mean that Roseburia plays an important role in maintaining a healthy gut and reducing the risk of these conditions.9Tamanai-Shacoori, Z., Smida, I., Bousarghin, L., Loreal, O., Meuric, V., Fong, S. B., Jolivet-Gougeon, A. (2017). Roseburia spp.: a marker of health? Future Microbiol, 12(2), 157-170. doi: 10.2217/fmb-2016-013010Al-Jameel SS. Association of diabetes and microbiota: An update. Saudi J Biol Sci. 2021 Aug;28(8):4446-4454. doi: 10.1016/j.sjbs.2021.04.041.11Liu BN, Liu XT, Liang ZH, Wang JH. Gut microbiota in obesity. World J Gastroenterol. 2021 Jul 7;27(25):3837-3850. doi: 10.3748/wjg.v27.i25.3837.

What are the best sources of Roseburia?

Roseburia is a native microbe of the human gut. There are no food sources. Food supplements are currently being developed.12Zhang J, Song L, Wang Y, Liu C, Zhang L, Zhu S, Liu S, Duan L. Beneficial effect of butyrate-producing Lachnospiraceae on stress-induced visceral hypersensitivity in rats. J Gastroenterol Hepatol. 2019 Aug;34(8):1368-1376. doi: 10.1111/jgh.14536.

What foods can Roseburia feed on?

Roseburia is a versatile microbe and can thrive on a wide range of fibre-rich foods, with a preference for food sources of soluble fibres, such as fruits, vegetables, whole grains, pulses/legumes, and nuts and seeds. Including a variety of these foods in your diet provides the necessary sources of nourishment for Roseburia to carry out its beneficial functions, promoting a healthy gut microbiome.13Nagpal R, Shively CA, Register TC, Craft S, Yadav H. Gut microbiome-Mediterranean diet interactions in improving host health. F1000Res. 2019 May 21;8:699. doi: 10.12688/f1000research.18992.1.

Where to find Roseburia in the Chuckling Goat Gut Microbiome Test

You will find your Roseburia score in the “Butyrate-producing bacteria” section of the “Probiotics” report in your Chuckling Goat Gut Microbiome Test results.

Synonyms: Roseburia intestinalis, R. intestinalis

Important disclaimer

The Chuckling Goat Gut Microbiome Handbook is an educational resource built to translate complex science into plain English. The information provided on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your GP or other qualified health provider with any questions you may have regarding a medical condition. Always check with your GP for interactions with medications/health conditions before changing your diet or starting to take food supplements.

References

  • 1
    Nie K, Ma K, Luo W, Shen Z, Yang Z, Xiao M, Tong T, Yang Y, Wang X. Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species. Front Cell Infect Microbiol. 2021 Nov 22;11:757718. doi: 10.3389/fcimb.2021.757718.
  • 2
    La Rosa, S.L., Leth, M.L., Michalak, L. et al. The human gut Firmicute Roseburia intestinalis is a primary degrader of dietary β-mannans. Nat Commun 10, 905 (2019). doi: 10.1038/s41467-019-08812-y
  • 3
    Machiels K, Joossens M, Sabino J, De Preter V, Arijs I, Eeckhaut V, Ballet V, Claes K, Van Immerseel F, Verbeke K, Ferrante M, Verhaegen J, Rutgeerts P, Vermeire S. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Gut. 2014 Aug;63(8):1275-83. doi: 10.1136/gutjnl-2013-304833.
  • 4
    Ruan G, Chen M, Chen L, Xu F, Xiao Z, Yi A, Tian Y, Ping Y, Lv L, Cheng Y, Wei Y. Roseburia intestinalis and Its Metabolite Butyrate Inhibit Colitis and Upregulate TLR5 through the SP3 Signaling Pathway. Nutrients. 2022 Jul 25;14(15):3041. doi: 10.3390/nu14153041.
  • 5
    Shen Z, Luo W, Tan B, Nie K, Deng M, Wu S, Xiao M, Wu X, Meng X, Tong T, Zhang C, Ma K, Liao Y, Xu J, Wang X. Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn’s disease. EBioMedicine. 2022 Nov;85:104285. doi: 10.1016/j.ebiom.2022.104285.
  • 6
    Nie K, Ma K, Luo W, Shen Z, Yang Z, Xiao M, Tong T, Yang Y, Wang X. Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species. Front Cell Infect Microbiol. 2021 Nov 22;11:757718. doi: 10.3389/fcimb.2021.757718.
  • 7
    Faruqui, N. A., Prium, D. H., Mowna, S. A., Ullah, M. A., Araf, Y., Sarkar, B., Rahman, M. S. (2021). Gut microorganisms and neurological disease perspectives. Future Neurology, 16(1), FNL53. doi: 10.2217/fnl-2020-0026
  • 8
    Hatziioanou D, Mayer MJ, Duncan SH, Flint HJ, Narbad A. A representative of the dominant human colonic Firmicutes, Roseburia faecis M72/1, forms a novel bacteriocin-like substance. Anaerobe. 2013 Oct;23:5-8. doi: 10.1016/j.anaerobe.2013.07.006.
  • 9
    Tamanai-Shacoori, Z., Smida, I., Bousarghin, L., Loreal, O., Meuric, V., Fong, S. B., Jolivet-Gougeon, A. (2017). Roseburia spp.: a marker of health? Future Microbiol, 12(2), 157-170. doi: 10.2217/fmb-2016-0130
  • 10
    Al-Jameel SS. Association of diabetes and microbiota: An update. Saudi J Biol Sci. 2021 Aug;28(8):4446-4454. doi: 10.1016/j.sjbs.2021.04.041.
  • 11
    Liu BN, Liu XT, Liang ZH, Wang JH. Gut microbiota in obesity. World J Gastroenterol. 2021 Jul 7;27(25):3837-3850. doi: 10.3748/wjg.v27.i25.3837.
  • 12
    Zhang J, Song L, Wang Y, Liu C, Zhang L, Zhu S, Liu S, Duan L. Beneficial effect of butyrate-producing Lachnospiraceae on stress-induced visceral hypersensitivity in rats. J Gastroenterol Hepatol. 2019 Aug;34(8):1368-1376. doi: 10.1111/jgh.14536.
  • 13
    Nagpal R, Shively CA, Register TC, Craft S, Yadav H. Gut microbiome-Mediterranean diet interactions in improving host health. F1000Res. 2019 May 21;8:699. doi: 10.12688/f1000research.18992.1.

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